Frequently Asked Questions

General

What is EIT Pathogena?

EIT Pathogena is a scalable software as a service designed for assembling, variant calling, and analysing pathogen sequences. This tool provides insights into identifying species, predicting drug susceptibility, and identifying clusters typical of outbreaks using cloud technologies globally. The first available pipeline covers Mycobacterium tuberculosis and Non-tuberculous mycobacteria, but further pipelines will be released in the near future.

Who developed EIT Pathogena?

EIT Pathogena, previously known as Global Pathogen Analysis Service (GPAS) Ltd, was developed by the Modernising Medical Microbiology group at the University of Oxford, led by Professor Derrick Crook. The project was initially established in September 2021 to distribute SARS-CoV-2 bioinformatics. Larry Ellison, founder and CTO of Oracle Inc, funded GPAS with the goal of building a genomic pathogen analysis platform. In 2024 GPAS joined the Ellison Institute of Technology Oxford under the Health & Medical Science Humane Endeavour.

What are the benefits of using EIT Pathogena?

Quality & Speed

It automates and speeds up analysis, providing a thorough, accurate, and reliable understanding of microbes within minutes instead of hours, including resistance prediction based on the 2nd edition of the WHO catalogue.

Cloud Data Management

EIT Pathogena offers automated, reliable, and accurate processing. Capable of extensive automation, including APIs, EIT Pathogena offers a range of flexible implementation options. Built on Oracle Cloud Infrastructure, privacy and security are at the heart of the design, ranging from data encryption to the latest developments in human read removal to minimise personally identifiable information. EIT Pathogena’s scalable cloud platform enables rapid analysis, accelerates results, and produces detailed reports.

Simplicity and Ease of Use

EIT Pathogena is designed with a user-friendly approach, featuring an optimised user experience validated by organisations worldwide. Thanks to its intuitive interface that requires no coding expertise, software engineers and bioinformaticians will have more time to focus on highly skilled tasks. Additionally, there are no set-up costs, as the platform eliminates the need for server investments or extra technology. Being cloud-based, it is accessible from anywhere at any time, making it convenient for a wide range of users, including public health teams and clinicians, to rapidly and accurately interpret results.

How do I start using EIT Pathogena?

As an individual, you can create a Personal Account:

  1. Click on Get Started

  2. Navigate to EIT Pathogena and click on “Sign Up”. Follow the instructions to create a user account.

  3. After completing the sign-up form, you will receive an email with instructions to set up your account password.

  4. Once your password is set, you'll receive a verification email. Click the link in the email to verify your account and email address. If you don’t receive the email, please contact pathogena.support@eit.org.

You are now ready to start using EIT Pathogena.

There is a separate process for signing up as an organisation.

What are the benefits of signing up as an organisation?

Signing up as an organisation with EIT Pathogena provides several valuable benefits. Firstly, it allows your designated team to access a centralised platform where all your sample analyses are stored. This centralisation simplifies data management and ensures that all team members can easily find and use the necessary results.

When you sign up, you can assign different user roles within your organisation. There are two user roles available: Standard and Super users. Standard users can access only the sample data they uploaded themselves or those explicitly shared with them. On the other hand, super users have broader access, enabling them to view all samples within the organisation.

If requested by the organisation, Super users are able to share data within their own organisation or with external organisations. This flexibility fosters collaboration and efficient data sharing within teams and external partners. Both Standard and Super users can see data shared from external organisations.

The procedure to sign up is straightforward. Simply contact us and provide the details of who you want to add to your team. We will guide you through the setup process, ensuring that your organisation is ready to take full advantage of the platform's features.

How can I access sharing?

Data sharing is available to organisations. Your organisation can gain access to this by opting in, and we can customise your sharing features. This enables seamless intra-organisation and inter-organisation collaboration. For more details, please contact us directly pathogena.info@eit.org

Is EIT Pathogena only for Mycobacterium tuberculosis?

Currently, EIT Pathogena only supports Mycobacterium analysis. However, we will soon release a generalised species analysis tool and a tiled amplicon tool for SARS-CoV-2 analysis. We are working hard to expand our offering to include other validated tools to support many other pathogens of interest, with an initial focus on:
  • E.coli

  • Staphylococcus aureus

  • Klebsiella spp.

  • Anicetobacter baumanii

  • Shigella spp.

  • Streptococcus pneumoniae

  • Neisseria gonorrhoeae

  • Salmonella spp

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What is the cost associated with EIT Pathogena?

EIT Pathogena is currently free for all individual users in LMICs, or who are based in HICs but are working with Mycobacterium samples collected from LMICs. Organisations based in HICs may also be able to access the system for free; please contact us at pathogena.info@eit.org to find out more.

What is the EIT Pathogena Credit System, and how does it work?

The EIT Pathogena Credit System is a flexible way to manage your usage on the platform. Upon signing up as an individual user, you will automatically receive 1,000 credits, which can be used immediately to upload samples for analysis. For organisational users, the initial credit amount is determined and agreed upon during the sign-up process. Credits are deducted each time you upload a sample. You can track your credit balance. If you run out of credits, you can easily request additional credits through the "Upload Sample" workflow or by emailing us at pathogena.support@eit.org. During this process, we may also ask for feedback on your experience using EIT Pathogena, helping us improve our services.

Technology

Once the sample is uploaded, how long does it take to process a genomic sequence on EIT Pathogena?

EIT Pathogena is fast. It can process data for about 100 samples in an hour.

What is the difference between Standard and Super users? (for organisations only)

EIT Pathogena has two user roles available. These are Standard and Super users. Standard users can only access samples they have uploaded themselves, or those explicitly shared with them. Super users may access all samples within an organisation, or those shared by other organisations. Additionally, Super users can select which samples or batches to share with other predefined organisations.

Who owns the data uploaded on EIT Pathogena?

For individuals: Any intellectual property rights in the data and content you upload to, create, or generate using the Pathogena Web Portal and Services, including the results, belong to you. You and your licensors retain ownership of all intellectual property rights in your materials and uploaded data.

We grant you a worldwide, non-exclusive, non-assignable, and non-transferable royalty-free license to copy the deliverables during the term of this agreement. This license is for personal, non-clinical academic, and research purposes only. You cannot sub-license, assign, or transfer these rights to any third party. For more details, see our End User License Agreement (EULA).

For organisations: data ownership is defined in a separate agreement.

What is the EIT Pathogena approach to privacy and security?

EIT Pathogena is designed with privacy and security at its core. Built on the secure infrastructure of Oracle Cloud, EIT Pathogena adopts a robust approach to securing all customer data. EIT Pathogena also empowers users to ensure all personal data is anonymised prior to upload by using our command line tool. Alternatively, users can opt to upload genomic data directly to the portal, with data anonymisation and human read removal processes being completed shortly after upload.

Our approaches to security follow industry best practice including ensuring data is encrypted as rest and in transit, our engineers have segregated roles and we follow the principle of least privilege where access is only granted as necessary to deliver the service. EIT Pathogena utilises several autonomous products to ensure security patches are applied to services in a timely manner.

Where is the data hosted?

EIT Pathogen is hosted in the data centre of Oracle Cloud in London, UK. Please contact us for other data residency requirements.

What data is being uploaded to the cloud? Is any personally identifiable information (PII) being uploaded?

When you submit samples for processing this will include FastQ files and summary information about the sample such as dates and approximate geographic location.

Personally identifiable information could be uploaded into the system if a FastQ file contains human reads or if a subject name is included in the file name for example. If data does not contain human reads, then the web portal upload can directly process samples without concern. However, we also have a command line tool which can be used to remove human reads and submit the sample data for processing.

How does EIT Pathogena handle human read removal?

There are multiple ways to upload data into EIT Pathogena. This enables you to have full control over PII. If your sample data contains genomic PII, you can use our command line tool for human read removal prior to upload.

Alternatively, you can drop and drag files directly into the portal. Once uploaded, they will immediately have human reads removed, and the original files will be deleted.

Data is processed within an Oracle data centre in London, UK. Please ensure that you are aware of any local legal requirements on the handling of your data prior to uploading.

What sequencing technology do I need to use EIT Pathogena?

EIT Pathogena supports Illumina FASTQ files. If you have other platforms in mind that you would like to use, including Oxford Nanopore, please get in touch with us. We are committed to expanding our support and are open to accommodating your specific needs to enhance your research and collaboration experience. Your input helps us continually improve and provide the best possible service.

What technical support is available for using EIT Pathogena?

Our portal includes built-in support features, providing instant access to resources and troubleshooting guides. Additionally, our support team is available to assist you with any technical issues or questions pathogena.support@eit.org.

How does EIT Pathogena handle re-analysis of sample data over time?

EIT Pathogena currently does not re-analyse samples once uploaded. However, you may re-upload the same sample to be analysed with the newest released updates.

Who can access data uploaded to EIT Pathogena?

Individuals can access the data they uploaded.

For organisations: members of organisation based on their user role and data sharing within or external to the organisation as specified. In order to provide the services, and in line with the End User Licence Agreement, Ellison Oxford Limited employees and approved third-party contractors who provide support may access data on limited occasions to provide, support and improve the services.

Other

Are there opportunities for collaboration and partnership?

We actively seek to work with organisations and researchers to drive innovation and achieve shared goals. By partnering with us, you can leverage our expertise and resources, access advanced data-sharing tools, and participate in groundbreaking projects. If you are interested in exploring collaboration possibilities, please contact us to discuss how we can work together to advance our mutual interests.

Legal

What legal arrangements are required to use EIT Pathogena?

Individual users will be required to read and sign an End User Licence Agreement (EULA).

Organisations will require a Master Services Agreement (MSA).

Can I publish the results of the analysis I conducted using EIT Pathogena?

EIT Pathogena supports and encourages the publication of academic papers based on results from EIT Pathogena analysis.

In the event that you make public any results or any data obtained from the results, please include a statement identifying and acknowledging the use of the EIT Pathogena Web Portal and any contributing organisations in the development of such results.

For the avoidance of doubt, only results and not raw shared data can be published.

Please include the following wording in any such publication: “With thanks to the support of EIT Pathogena in this work, and [if relevant] to [the organisations] who chose to share their data.”